CTCAE v4.0 SOC MedDRA v12.0 Code CTCAE v4.0 Term Lay Term

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Blood and lymphatic system disorder

1000227

nemi

Lack of enough red blood cells (anemia

)

Blood and lymphatic system disorders 10005329

Blood and lymphatic system disorders -

Other, [add AE here] N/A

Blood and lymphatic system disorder

1004858

Bone marrow hypocellula

Decreased number of blood cells in the bone marro

Blood and lymphatic system disorder

1001344

Disseminated intravascular coagulatio

bnormal blood clotting and/or bleedin

Blood and lymphatic system disorders 10016288 Febrile neutropenia

Fever associated with dangerously low levels of a type of whit

blood cell (neutrophils)

Blood and lymphatic system disorder

10019491 Hemolysi

Destruction of red blood cell

Blood and lymphatic system disorders 10019515 Hemolytic uremic syndrome

Collection of signs including hemolytic anemia (destruction of re

blood cells), kidney failure and a low platelet (a type of blood cell

that helps to clot blood) count

Blood and lymphatic system disorders 10024378 Leukocytosis

Increased number of white blood cells (leukocytes) in the periphera

blood

Blood and lymphatic system disorder

1002518

Lymph node pai

Painful sensation in a lymph nod

Blood and lymphatic system disorder

1004163

Spleen disorde

bnormality of the splee

Blood and lymphatic system disorders 10043648 Thrombotic thrombocytopenic purpura

Formation of blood clots in small blood vessels around the bod

that leads to a low platelet (a type of blood cell that helps to clot

blood) count

Cardiac disorders 10051592 Acute coronary syndrome

on o

gns an

symp

oms

e su

ear

disease in which the heart does not get enough oxygen. Sudden

symptoms such as chest pain, shortness of breath, or fainting could

indicate heart disease and should be reported right away. Signs

such as abnormal EKG and blood tests can confirm damage to the

heart.

Cardiac disorders 10061589 Aortic valve disease

bnormal function of the aortic valve (one of the four valves in the

heart)

Cardiac disorder

1000358

systol

Type of cardiac arres

Cardiac disorders 10003658 Atrial fibrillation

bnormally fast irregular heartbeat involving the upper chambers o

the heart (atria)

Cardiac disorders 10003662 Atrial flutter

bnormally fast regular heartbeat involving the upper chambers o

the heart (atria)

Cardiac disorders 10003673 Atrioventricular block complete

Irregular heartbeat. A complete blockage of electrical signals from

the upper chambers of the heart (atria) to the lower chambers.

(ventricle)

Cardiac disorders 10003674 Atrioventricular block first degree

Delay of electrical signals as they pass through the heart's

conduction system. Generally no clinical symptoms are associated

with this and it is determined by EKG pattern.

Cardiac disorder

1000751

Cardiac arres

The heart stops pumping bloo

Cardiac disorder

10007541 Cardiac disorders - Other, [add AE here

]

Cardiac disorders 10008481 Chest pain - cardiac

Sudden onset of chest pain due to not enough blood going to th

heart

Cardiac disorders 10010276 Conduction disorder

bnormality of the the conduction (the progression of electrical

impulses through the heart which cause the heart to beat) of the

heart

Cardiac disorders 10010783 Constrictive pericarditis

Inflammation (swelling and redness) of the sac-like covering of the

heart (the pericardium) causing abnormal heart function

Cardiac disorders 10019279 Heart failure

Heart failure: inability of the heart to adequately pump blood t

supply oxygen to the body

Cardiac disorders 10069501 Left ventricular systolic dysfunction

Decrease in heart's ability to pump blood during the "active" phas

of the heartbeat (systole)

Cardiac disorders 10061532 Mitral valve disease

Defect in mitral valve (a valve in the heart that lies between the lef

atrium [upper chamber] and the left ventricle [lower chamber])

structure or function

Cardiac disorders 10027786 Mobitz (type) II atrioventricular block

Irregular heartbeat. A delay or blockage o

electrical signals

rom

one part of the heart (atrium) to another (ventricle). Missed

heartbeats occur suddenly and unexpectedly. Determined by EKG

pattern.

Cardiac disorders 10027787 Mobitz type I

Irregular heartbeat, delay, or blockage of electrical signals from one

part of the heart (atrium) to another (ventricle). The electrical

impulses are delayed further and further with each heartbeat until a

beat is skipped entirely. Determined by EKG pattern.

Cardiac disorders 10028596 Myocardial infarction

Heart attack caused by a blockage or decreased blood supply to

the heart

Cardiac disorder

1002860

Myocarditi

Inflammation (swelling and redness) of the heart muscl

Cardiac disorders 10033557 Palpitations

Unpleasant sensation of irregular and/or forceful beating of th

heart

Cardiac disorders 10034040 Paroxysmal atrial tachycardia

Period of very rapid and regular heartbeats that begins and end

suddenly

Cardiac disorder

1003447

Pericardial effusio

Fluid in the sac around the hear

Cardiac disorders 10053565 Pericardial tamponade

ompression o

the heart that occurs when blood or

luid builds u

in the space between the myocardium (the muscle of the heart) and

the pericardium (the outer covering sac of the heart) preventing

enough blood delivery

Cardiac disorder

1003448

Pericarditi

Inflammation (swelling and redness) of the sac around the hea

Cardiac disorders 10061541 Pulmonary valve disease

Problem that affects the pulmonary valve (a valve between the

heart and the artery that leads to the lungs)

Cardiac disorders 10038748 Restrictive cardiomyopathy

Stiffness in the heart preventing the heart chambers to properly fill

with blood

Cardiac disorders 10058597 Right ventricular dysfunction

Failure of the right lower chamber of the heart (ventricle) caused b

long-term high blood pressure in the lungs

Cardiac disorders 10040639 Sick sinus syndrome

ollection o

heart rhythm signs

symptoms that include:

inu

bradycardia (a slow heartbeat, Tachycardias (a fast heartbeat),

Bradycardia-tachycardia (an alternating slow and fast heart

rhythms)

Cardiac disorder

10040741 Sinus bradycardi

Slow heartbeat; regular rhyth

Cardiac disorder

1004075

Sinus tachycardi

Fast heartbeat; regular rhyth

Cardiac disorders 10042604 Supraventricular tachycardia

Fast heartbeat usually originating in an area located above th

ventricles

Cardiac disorders 10061389 Tricuspid valve disease

Defect in the function of the tricuspid valve (a valve between th

right upper [atria] and lower chambers [ventricles] of the heart)

Cardiac disorders 10047281 Ventricular arrhythmia

Irregular heartbeat resulting from an abnormality in the one of th

lower chambers of the heart (ventricle)

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Cardiac disorders 10047290 Ventricular fibrillation

Ventricular

ibrillation: irregular heartbeat that involves the lowe

chambers of the heart (ventricles) that results in uncoordinated

contraction of the heart; life threatening and potentially fatal,

needing immediate attention

Cardiac disorders 10047302 Ventricular tachycardia

Rapid heartbeat of one of the lower chambers (ventricle) of the

heart; regular rhythm but potentially life-threatening, needs

immediate attention

Cardiac disorder

1004801

Wolff-Parkinson-White syndrom

Rapid heart rate caused by extra electrical pathway in the hea

Congenital, familial and genetic disorders 10010331

Congenital, familial and genetic disorders -

Other, [add AE here] N/A

Ear and labyrinth disorders 10013993

Ear and labyrinth disorders - Other, [add AE

here] N/A

Ear and labyrinth disorder

1001402

Ear pain Earache or ear pai

Ear and labyrinth disorders 10065837 External ear inflammation

Inflammation (swelling and redness) of the skin of outer ear and

canal

Ear and labyrinth disorder

1006578

External ear pai

Painful sensation in the external ear regio

Ear and labyrinth disorder

1001924

Hearing impaire

Hearing los

Ear and labyrinth disorder

1006583

Middle ear inflammatio

Inflammation (swelling and redness) to the middle ea

Ear and labyrinth disorder

1004388

Tinnitu

Noise in the ears, such as ringing, buzzing, roaring, clickin

Ear and labyrinth disorder

1004734

Vertigo Feeling of spinning or whirlin

Ear and labyrinth disorders 10047386 Vestibular disorder

Problem of the inner ear that can cause dizziness, imbalance,

nausea, and vision problems

Endocrine disorders 10001367 Adrenal insufficiency

Inability of the adrenal glands (triangle-shaped glands located on

top of the kidneys) to produce a normal quantity of hormones

Endocrine disorders 10011655 Cushingoid

Problem characterized by signs that resemble Cushing's disease or

syndrome due to too much steroids

Endocrine disorder

1001220

Delayed pubert

Unusually late sexual maturit

Endocrine disorders 10014698 Endocrine disorders - Other, [add AE here] N/A

Endocrine disorder

1001874

Growth accelerate

Growth greater than expected for ag

Endocrine disorders 10020705 Hyperparathyroidism

High level of hormone of the parathyroid glands causing high bloo

calcium levels (hypercalemia) and low blood phosphate

(hypophosphaemia)

Endocrine disorder

1002085

Hyperthyroidis

bnormally high level of thyroid gland hormon

Endocrine disorder

10021041 Hypoparathyroidis

bnormally low level of parathyroid glands hormon

Endocrine disorder

1002111

Hypothyroidis

bnormally low level of thyroid gland hormon

Endocrine disorder

1005808

Precocious pubert

Unusually early onset of sexual maturation (pubert

Endocrine disorder

1004748

Virilizatio

Development of male physical characteristics in female

Eye disorder

1000588

Blurred visio

Eye disorder

1000773

Cataract Cloudiness of the eye (cataract

)

Eye disorders 10010741 Conjunctivitis

Inflammation (swelling and redness) of the conjunctiva (the

outermost layer of the eye and the inner surface of the eyelids).

Commonly called "pink eye".

Eye disorders 10048492 Corneal ulcer

Open sore in the cornea (the transparent area at the front of the

eyeball)

Eye disorder

1001377

Dry ey

Eye disorders 10015829 Extraocular muscle paresis

Loss of muscle function of an extraocular muscle (one of the

muscles that control movement of the eye)

Eye disorders 10015919

Eye disorders - Other, [pressure one ey,

eye swelling] Pressure on eye, eye swelling

Eye disorder

1001595

Eye pai

Eye disorder

1006114

Eyelid function disorde

Problem with eyeli

Eye disorder

1001675

Flashing light

Seeing flashing light

Eye disorder

1001677

Floaters Seeing spots before the eyes (floaters

)

Eye disorder

1001830

Glaucom

Increased pressure in the eyeball (glaucoma

)

Eye disorders 10023332 Keratitis

Inflammation (swelling and redness) of the cornea (the transparen

front cover of the eye)

Eye disorder

1002940

Night blindnes

Inability to see in dim light (night blindness

Eye disorder

1006132

Optic nerve disorde

bnormal function of the nerve responsible for sigh

Eye disorder

1003370

Papilledem

Swelling around the nerve responsible for sigh

Eye disorder

1003496

Photophobi

Fear of ligh

Eye disorders 10038848 Retinal detachment

Separation of the retina (a multi-layered sensory tissue that lines th

back of the eye responsible for sight) from its connection at the

back of the eye

Eye disorders 10038897 Retinal tear

Small tearing of the retina (a multi-layered sensory tissue that line

the back of the eye responsible for sight)

Eye disorders 10038901 Retinal vascular disorder

Problem that affect blood vessels in and around the retina (a multi

layered sensory tissue that lines the back of the eye responsible for

sight)

Eye disorders 10038923 Retinopathy

Problem of the retina (a multi-layered sensory tissue that lines th

back of the eye responsible for sight)

Eye disorder

1006151

Scleral disorde

Problem affecting the sclera (the white of the eye)

Eye disorders 10046851 Uveitis

Inflammation (swelling and redness) of the middle layer of the ey

(uvea)

Eye disorders 10047656 Vitreous hemorrhage

Rupture of blood vessels in the retina causing bleeding into th

vitreous humor (the clear gel/fluid that fills the eyeball)

Eye disorder

1004784

Watering eyes Excessive tearing in the eye

Gastrointestinal disorders 10000060 Abdominal distension Swelling or feeling of fullness and tightness in the abdomen (belly)

Gastrointestinal disorder

10000081

bdominal pai

Belly pai

Gastrointestinal disorder

1000215

nal fistul

Hole between anus and another orga

Gastrointestinal disorder

1005522

nal hemorrhag

bleeding in the anal regio

Gastrointestinal disorder

10065721

nal mucositi

Irritation or sores in the lining of the anu

Gastrointestinal disorder

1006572

nal necrosi

Death of tissue of the anu

Gastrointestinal disorder

1000216

nal pai

Gastrointestinal disorder

1000217

nal stenosi

Narrowing of the anal cana

Gastrointestinal disorder

1000218

nal ulce

Sore in the lining of the anu

Gastrointestinal disorder

1000344

scites Fluid collection in the abdome

Gastrointestinal disorder

1000526

Bloating Feeling of fullness and tightness in the bell

Gastrointestinal disorder

1006574

Cecal hemorrhag

Bleeding in the cecum (a portion of the large bowel

Gastrointestinal disorder

1000841

Cheiliti

Inflammation (swelling and redness) of the li

Gastrointestinal disorder

1000988

Coliti

Inflammation (swelling and redness) of the large bowel (colon

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Gastrointestinal disorder

1000999

Colonic fistul

Hole between large bowel and another orga

Gastrointestinal disorder

1000999

Colonic hemorrhag

Bleeding in the large bowe

Gastrointestinal disorder

1001000

Colonic obstructio

Blockage in the large bowe

Gastrointestinal disorder

10010001 Colonic perforatio

Hole in the large bowe

Gastrointestinal disorder

1001000

Colonic stenosi

Narrowing of the large bowe

Gastrointestinal disorder

1001000

Colonic ulce

Sore (ulcer) in the lining of the large bow

Gastrointestinal disorder

1001077

Constipatio

Gastrointestinal disorder

1001231

Dental carie

Cavities or tooth deca

Gastrointestinal disorder

1001272

Diarrhe

Gastrointestinal disorder

10013781 Dry mouth Dry mouth

Gastrointestinal disorders 10013828 Duodenal fistula

Hole between an area in the small bowel (duodenum) and anothe

organ

Gastrointestinal disorder

1005524

Duodenal hemorrhag

Bleeding in or from an area of the small bowel (duodenum

Gastrointestinal disorder

1001383

Duodenal obstructio

Blockage of an area of the small bowel (duodenum

)

Gastrointestinal disorder

1001383

Duodenal perforatio

Hole in an area of the small bowel (duodenum

Gastrointestinal disorder

1005009

Duodenal stenosi

Narrowing of an area of the small bowel (duodenum

Gastrointestinal disorders 10013836 Duodenal ulcer Sore (ulcer) in the lining of an area of the small bowel (duodenum)

Gastrointestinal disorder

1001394

Dyspepsi

Heartbur

Gastrointestinal disorder

1001395

Dysphagi

Difficulty swallowin

Gastrointestinal disorders 10014893 Enterocolitis Inflammation (swelling and redness) of the small and large bowel

Gastrointestinal disorders 10062570 Enterovesical fistula Hole between the urinary bladder and some part of the intestines

Gastrointestinal disorders 10065851 Esophageal fistula

Hole between the esophagus (gullet or the tube that goes from

mouth to stomach through which food passes) and another organ

Gastrointestinal disorders 10015384 Esophageal hemorrhage

Bleeding in the esophagus (gullet or the tube that goes from the

mouth to the stomach)

Gastrointestinal disorders 10065727 Esophageal necrosis

Death of tissue in the esophagus (gullet or the tube that goes from

mouth to stomach through which food passes)

Gastrointestinal disorders 10015387 Esophageal obstruction

Blockage of the esophagus (gullet or the tube that goes from mouth

to stomach through which food passes)

Gastrointestinal disorders 10015388 Esophageal pain

Pain in the esophagus (gullet or the tube that goes from mouth to

stomach through which food passes)

Gastrointestinal disorders 10055472 Esophageal perforation

Hole in the esophagus (gullet or the tube that goes from mouth to

stomach through which food passes)

Gastrointestinal disorders 10015448 Esophageal stenosis

Narrowing of the esophagus (gullet or the tube that goes from

mouth to stomach through which food passes)

Gastrointestinal disorders 10015451 Esophageal ulcer

Sore (ulcer) in the lining of the esophagus (gullet or the tube tha

goes from mouth to stomach through which food passes)

Gastrointestinal disorders 10015453 Esophageal varices hemorrhage

Bleeding in or from the blood vessels in the esophagus (gullet o

the tube that goes from the mouth to the stomach) because of

varices (enlargement of the veins of the esophagus)

Gastrointestinal disorders 10015461 Esophagitis

Inflammation (swelling and redness) of the esophagus (gullet or the

tube that goes from mouth to stomach through which food passes)

Gastrointestinal disorders 10016296 Fecal incontinence

Inability to control bowel movements thus allowing the escape o

feces from the rectum

Gastrointestinal disorder

1001676

Flatulenc

Excess passing of gas

Gastrointestinal disorder

1006571

Gastric fistula Hole between the stomach and another orga

Gastrointestinal disorder

1001778

Gastric hemorrhag

Bleeding in or from the stomac

Gastrointestinal disorder

1005188

Gastric necrosis Death of tissue of the stomach linin

Gastrointestinal disorder

1001781

Gastric perforation Hole in the stomac

Gastrointestinal disorder

1006197

Gastric stenosis Narrowing of the stomac

Gastrointestinal disorder

1001782

Gastric ulce

Sore (ulcer) in the lining of the stomac

Gastrointestinal disorder

1001785

Gastritis Inflammation (swelling and redness) of the stomach linin

Gastrointestinal disorders 10066874 Gastroesophageal reflux disease

Excess amount o

gastric juice

lowing back

(

luxes

)

into the

esophagus (gullet or the tube that goes from mouth to stomach

through which food passes), causing heartburn and possibly

damaging the esophagus

Gastrointestinal disorders 10017947

Gastrointestinal disorders - Other, [add AE

here] N/A

Gastrointestinal disorders 10017877 Gastrointestinal fistula

Gastrointestinal fistula: Abnormal hole between an organ of th

digestive tract and another organ or tissue

Gastrointestinal disorder

1001799

Gastrointestinal pai

Pain in the digestive trac

Gastrointestinal disorders 10018043 Gastroparesis

Partial paralysis or loss of muscle function (paresis) of the stomach

("gastro-"), resulting in food remaining in the stomach for a longer

period of time than normal

Gastrointestinal disorder

1001828

Gingival pai

Pain in the gum

Gastrointestinal disorders 10060640 Hemorrhoidal hemorrhage

bleeding in hemorrhoids (swollen or irritated blood vessels in th

anus and rectum, also known as piles)

Gastrointestinal disorders 10019611 Hemorrhoids

Hemorrhoids (swollen or irritated blood vessels in the anus and

rectum). Also known as piles.

Gastrointestinal disorders 10065728 Ileal fistula Hole between an area in the small bowel (ileum) and another organ

Gastrointestinal disorder

1005528

Ileal hemorrhag

Bleeding in or from an area of the small bowel (ileum

)

Gastrointestinal disorder

1006573

Ileal obstructio

Blockage in an area of the small bowel (ileum

)

Gastrointestinal disorder

1002130

Ileal perforatio

Hole in an area of the small bowel (ileum

)

Gastrointestinal disorder

1002130

Ileal stenosi

Narrowing of a area of the small bowel (ileum

)

Gastrointestinal disorder

1002130

Ileal ulce

Sore (ulcer) in the lining in an area of the small bowel (ileum

Gastrointestinal disorders 10021328 Ileus

Partial or complete blockage of the small and/or large bowel. Ileus

is a functional rather than actual blockage of the bowel.

Gastrointestinal disorder

10055291 Intra-abdominal hemorrhag

Bleeding in the bell

Gastrointestinal disorders 10065719 Jejunal fistula

Hole between an area in the small bowel (jejunum) and anothe

organ

Gastrointestinal disorder

1005530

Jejunal hemorrhag

Bleeding in an area of the small bowel (jejunum

)

Gastrointestinal disorder

1006573

Jejunal obstructio

Blockage in an area of the small bowel (jejunum

)

Gastrointestinal disorder

1002317

Jejunal perforatio

Hole in an area of the small bowel (jejunum

)

Gastrointestinal disorder

1002317

Jejunal stenosi

Narrowing of a area of the small bowel (jejunum

)

Gastrointestinal disorder

1002317

Jejunal ulce

Sore (ulcer) in the lining in an area of the small bowel (jejunum

Gastrointestinal disorder

10024561 Lip pai

Lip pai

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Gastrointestinal disorders 10051746 Lower gastrointestinal hemorrhage

Bleeding in some portion of the lower gastrointestinal tract (small

bowel, large bowel, and anus)

Gastrointestinal disorders 10025476 Malabsorption

Inability to absorb nutrients (certain sugars, fats, proteins, or

vitamins from food). It can also involve a general inability to absorb

food.

Gastrointestinal disorder

1002813

Mucositis ora

Irritation or sores in the lining of the mout

Gastrointestinal disorder

1002881

Nause

Nausea or the urge to vomi

Gastrointestinal disorder

1002995

Obstruction gastri

Blockage in the stomac

Gastrointestinal disorder

1006572

Oral cavity fistul

Hole between mouth and another orga

Gastrointestinal disorders 10054520 Oral dysesthesia Burning or tingling sensation on the lips, tongue, or entire mouth

Gastrointestinal disorder

1003098

Oral hemorrhag

Bleeding in or from the mout

Gastrointestinal disorder

1003100

Oral pai

Mouth pai

Gastrointestinal disorder

1006570

Pancreatic duct stenosi

Narrowing of the pancreatic duc

Gastrointestinal disorder

1004919

Pancreatic fistul

Hole between pancreas and another orga

Gastrointestinal disorder

1003362

Pancreatic hemorrhag

Bleeding in or from the pancrea

Gastrointestinal disorder

1005809

Pancreatic necrosi

Death of pancreas tissu

Gastrointestinal disorder

1003364

Pancreatiti

Inflammation (swelling and redness) of the pancrea

Gastrointestinal disorder

1003453

Periodontal diseas

Disease of the teeth or gum

Gastrointestinal disorders 10065704 Peritoneal necrosis

Problem o

the gums ranging

rom simple in

lammation

(

swelling

and redness) to major damage to the soft tissue and bone that

support the teeth. In the worst cases, teeth are lost.

Gastrointestinal disorder

1003677

Proctitis Inflammation (swelling and redness) of the lining of the rectu

Gastrointestinal disorder

1003806

Rectal fistul

Hole between rectum and another orga

Gastrointestinal disorder

1003806

Rectal hemorrhag

Bleeding in or from the rectu

Gastrointestinal disorder

1006319

Rectal mucositis Irritation or sores in the lining of the rectu

Gastrointestinal disorder

1006570

Rectal necrosi

Death of tissue of the rectu

Gastrointestinal disorder

1006570

Rectal obstructio

Blockage of the rectum

Gastrointestinal disorder

1003807

Rectal pai

Gastrointestinal disorder

1003807

Rectal perforatio

Hole in the rectu

Gastrointestinal disorder

1003807

Rectal stenosi

Narrowing of the rectu

Gastrointestinal disorder

1003808

Rectal ulce

Sore (ulcer) in the lining of the rectu

Gastrointestinal disorders 10038981 Retroperitoneal hemorrhage

bleeding in the retroperitoneal area (the space in the belly behind

the peritoneum (the tissue that hold the organs in the abdomen)

Gastrointestinal disorders 10056681 Salivary duct inflammation

Inflammation (swelling and redness) of the salivary duct (a tube

through which saliva (spit) is carried from the salivary gland to the

mouth)

Gastrointestinal disorder

10039411 Salivary gland fistul

Hole between saliva (spit)-producing gland and another orga

Gastrointestinal disorder

1006571

Small intestinal mucositi

Irritation or sores in the lining of the small bow

Gastrointestinal disorder

10041101 Small intestinal obstructio

Blockage of the small bowe

Gastrointestinal disorder

1004110

Small intestinal perforatio

Hole in the small bowe

Gastrointestinal disorder

1006226

Small intestinal stenosi

Narrowing of the small bowe

Gastrointestinal disorder

1004113

Small intestine ulce

Sore (ulcer) in the lining of the small bow

Gastrointestinal disorder

1004211

Stomach pai

Gastrointestinal disorder

1004403

Tooth development disorde

Problems with tooth growt

Gastrointestinal disorder

10044031 Tooth discoloratio

Change in tooth colo

Gastrointestinal disorder

1004405

Toothach

Gastrointestinal disorders 10045271 Typhlitis

Imflammation (swelling and redness) and/or necrosis (death of

tissue) of the appendix. cecum, and/or ileum (both areas of the

large bowel)

Gastrointestinal disorders 10055356 Upper gastrointestinal hemorrhage

Bleeding in the upper digestive tract (mouth, pharynx, esophagus

[gullet or the tube that goes from mouth to stomach through which

food passes], and stomach)

Gastrointestinal disorder

1004770

Vomiting Vomiting

General disorders and administration site

conditions 10008531 Chills Chills

General disorders and administration site

conditions 10011912 Death neonatal Death of infant within 28 days of birth

General disorders and administration site

conditions 10011914 Death NOS Death of unknown cause

General disorders and administration site

conditions 10014222 Edema face Swelling of the face

General disorders and administration site

conditions 10050068 Edema limbs Swelling of the arms and/or legs

General disorders and administration site

conditions 10058720 Edema trunk Swelling of the trunk of the body

General disorders and administration site

conditions 10016059 Facial pain Face pain

General disorders and administration site

conditions 10016256 Fatigue Fatigue or tiredness

General disorders and administration site

conditions 10016558 Fever Fever

General disorders and administration site

conditions 10016791 Flu like symptoms

Flu-type symptoms (including body aches, fever, chills, tiredness,

loss of appetite, cough)

General disorders and administration site

conditions 10017577 Gait disturbance Limp or difficulty walking

General disorders and administration site

conditions 10018065

General disorders and administration site

conditions - Other, [add AE here] N/A

General disorders and administration site

conditions 10021113 Hypothermia Low body temperature

General disorders and administration site

conditions 10051792 Infusion related reaction

Reaction that can occur during or following infusion of the drug.

The reaction may include fever, chills, rash, low blood pressure, an

difficulty breathing.

General disorders and administration site

conditions 10064774 Infusion site extravasation

Leaking of drug from blood vessel into tissue surrounding the

injection site

General disorders and administration site

conditions 10022095 Injection site reaction

Inflammation (swelling and redness) or damage to the tissue

surrounding where a drug was injected

General disorders and administration site

conditions 10022998 Irritability Irritability

General disorders and administration site

conditions 10062466 Localized edema Swelling localized to some part of the body

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General disorders and administration site

conditions 10025482 Malaise General feeling of discomfort or being unwell or out of sorts

General disorders and administration site

conditions 10028154 Multi-organ failure

Progressive failure of the lungs, liver, kidney, and clotting

mechanisms

General disorders and administration site

conditions 10054482 Neck edema Swelling of the neck

General disorders and administration site

conditions 10062501 Non-cardiac chest pain Chest pain not heart-related

General disorders and administration site

conditions 10033371 Pain Pain

General disorders and administration site

conditions 10042435 Sudden death NOS Sudden death of unknown cause(s)

Hepatobiliary disorder

10051341 Bile duct stenosi

Narrowing of bile duct

Hepatobiliary disorder

1000466

Biliary fistul

Hole between bile ducts and another orga

Hepatobiliary disorders 10008612 Cholecystitis

Inflammation (swelling and redness) of the gallbladder possibl

associated with gallstones

Hepatobiliary disorder

10017631 Gallbladder fistul

Hole between bile ducts and another orga

Hepatobiliary disorder

1005944

Gallbladder necrosi

Death of tissue in the gallbladde

Hepatobiliary disorder

1001763

Gallbladder obstructio

Blockage in the bile duct

Hepatobiliary disorder

1001763

Gallbladder pai

Pain in or around the gallbladde

Hepatobiliary disorder

1001763

Gallbladder perforatio

Hole in the gallbladder wal

Hepatobiliary disorder

1001966

Hepatic failur

Liver failur

Hepatobiliary disorder

1001967

Hepatic hemorrhag

Bleeding in or from the live

Hepatobiliary disorder

1001969

Hepatic necrosi

Death of liver tissu

Hepatobiliary disorder

1001970

Hepatic pai

Liver pai

Hepatobiliary disorders 10019805

Hepatobiliary disorders - Other, [add AE

here] N/A

Hepatobiliary disorder

1003440

Perforation bile duc

Hole in the bile duct

Hepatobiliary disorders 10036200 Portal hypertension

Increased blood pressure in the system o

veins called the portal

venous system (blood vessels coming from the stomach, intestine,

spleen, and pancreas, merging into the portal vein that flows to the

liver)

Hepatobiliary disorders 10036206 Portal vein thrombosis

Blood clot in hepatic (liver) portal vein (a major blood vessel in the

abdominal cavity that drains blood from the digestive tract and

spleen)

Immune system disorders 10001718 Allergic reaction

llergic reaction by your body to the drug product that can occu

immediately or may be delayed. The reaction may include hives,

low blood pressure, wheezing, swelling of the throat, and difficulty

breathing.

Immune system disorders 10002218 Anaphylaxis

erious, li

e-threatening allergic reaction requiring immediate

medical treatment by your doctor. The reaction may include

extremely low blood pressure, swelling of the throat, difficulty

breathing, and loss of consciousness.

Immune system disorders 10061664 Autoimmune disorder

Destruction of a person's own healthy body tissue by their ow

immune system

Immune system disorders 10052015 Cytokine release syndrome

Potentially life-threatening condition during a drug infusion which

may cause low blood pressure, rash, fever, chills, difficulty

breathing, rapid heartbeat, nausea, and kidney damage

Immune system disorders 10021428

Immune system disorders - Other, [add AE

here] N/A

Immune system disorders 10040400 Serum sickness

llergic reaction to certain medications, injected proteins, or

antisera (blood product) used to treat certain medical conditions

(such as an infectious or poisonous substance)

Infections and infestation

1005651

bdominal infectio

Infection of the bell

Infections and infestation

1006164

norectal infectio

Infection of the anal or rectal are

Infections and infestations 10003011 Appendicitis

Painful inflammation (swelling and redness) of the appendix usuall

caused by an infection

Infections and infestations 10003012 Appendicitis perforated

Type of appendicitis when a hole develops in the inflamed appendi

through which all of the contents that were in the appendix leaks ou

into the abdominal cavity

Infections and infestations 10065744 Arteritis infective

Infection of an artery (a blood vessel that carries blood away from

the heart)

Infections and infestation

1006169

Biliary tract infectio

Bile duct infectio

Infections and infestation

1000504

Bladder infectio

Infections and infestation

1006101

Bone infectio

Infections and infestation

1000625

Breast infectio

Infections and infestation

1005507

Bronchial infectio

Infection of the air tube from the windpipe to the lung

Infections and infestation

1000781

Catheter related infectio

Infection caused by use of a cathete

Infections and infestation

10065761 Cecal infectio

Infection of area of large bowel (cecum

)

Infections and infestation

1000833

Cervicitis infectio

Infection of the cervix (the lower end of the uterus [womb]

)

Infections and infestations 10010742 Conjunctivitis infective

Inflammation (swelling and redness) of the conjunctiva (the

membrane that lines the eyelids and covers the exposed surface of

the eyeball) caused by an infection

Infections and infestation

1006178

Corneal infectio

Infection of clear front part of the eyeball (cornea

)

Infections and infestations 10065765 Cranial nerve infection

Infection of the nerves that come from the brain and exit through

openings in the skull

Infections and infestation

1006468

Device related infectio

Infection at lthe location of a medical devic

Infections and infestation

1006575

Duodenal infectio

Infection of the duodenum (area of small bowel

)

Infections and infestation

1001459

Encephalitis infectio

Brain infectio

Infections and infestation

10014621 Encephalomyelitis infectio

Brain and spinal cord infectio

Infections and infestations 10014678 Endocarditis infective

Infection of the the endocardial layer of the heart (the innermos

layer of tissue that lines the chambers of the heart)

Infections and infestations 10014801 Endophthalmitis Inflammation (swelling and redness) of the internal parts of the eye

Infections and infestation

1005883

Enterocolitis infectiou

Infection of both the small and large bowe

Infections and infestations 10058804 Esophageal infection

Infection of the esophagus (gullet or the tube that goes from the

mouth to the stomach)

Infections and infestation

1001592

Eye infectio

Infection of the ey

Infections and infestation

1006263

Gallbladder infectio

Infections and infestation

1001878

Gum infectio

Infection of the gum

Infections and infestation

1005652

Hepatic infectio

Liver infectio

Infections and infestation

1001979

Hepatitis viral Disorder of the liver caused by a viru

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Infections and infestations 10021881

Infections and infestations - Other, [add AE

here] N/A

Infections and infestation

1002191

Infective myositi

Infection of skeletal muscle

Infections and infestation

1002321

Joint infectio

Infections and infestation

1002342

Kidney infectio

Infections and infestations 10023874 Laryngitis

Inflammation (swelling and redness) of the voice box (larynx) that i

usually associated with hoarseness or loss of voice

Infections and infestation

1006575

Lip infectio

Infection of the lip or area around the mout

Infections and infestation

1006122

Lung infectio

Infections and infestation

1005082

Lymph gland infectio

Infection of lymph node/glan

Infections and infestations 10057483 Mediastinal infection

Infection of the mediastinum (the "middle" section of the chest

cavity which contains all of the chest organs except the lungs)

Infections and infestations 10027199 Meningitis

Inflammation (swelling and redness) of the connective tissue

surrounding the brain and spinal cord usually a result of infection

Infections and infestation

1006576

Mucosal infectio

Infection of the tissue that lines body parts (mucosa

)

Infections and infestation

1006130

Nail infectio

Infection of the finger or toenail

Infections and infestation

1003307

Otitis extern

Infection of the outer ear and ear cana

Infections and infestation

1003307

Otitis media Middle ear infectio

Infections and infestation

1005500

Ovarian infectio

Infection of the ovarie

Infections and infestation

10051741 Pancreas infectio

Pancreas infectio

Infections and infestations 10069138 Papulopustular rash

Rash made up of papules (a small, raised pimple) and pustules (a

small pus filled blister), typically appearing in face, scalp, and upper

chest

Infections and infestation

1003401

Paronychi

Infection of the soft tissue around a fingernai

Infections and infestation

1005867

Pelvic infectio

Infection of the pelvi

Infections and infestation

1006191

Penile infectio

Infection of the peni

Infections and infestation

1005147

Periorbital infectio

Infection of the soft tissues around the eye socke

Infections and infestations 10065766 Peripheral nerve infection

Infection of the peripheral nerves (nerves in the face, arms, legs,

torso, and some cranial nerves of the head)

Infections and infestation

1005726

Peritoneal infectio

Infection of the lining of the abdominal cavit

Infections and infestation

1003483

Pharyngiti

Infection in the throat

Infections and infestation

1005662

Phlebitis infectiv

Infection in a vein causing swelling and irritation (phlebiti

Infections and infestation

10061351 Pleural infectio

Infection of the lining of the chest cavity and cover the lung

Infections and infestation

1005066

Prostate infectio

Infections and infestation

1003788

Rash pustula

Skin rash characterized by pus-containing blister

Infections and infestation

1005982

Rhinitis infectiv

Infection of the lining of the nos

Infections and infestation

1003941

Salivary gland infectio

Infections and infestation

1006215

Scrotal infectio

Infection of the scrotu

Infections and infestations 10040047 Sepsis Severe illness in which the bloodstream is overwhelmed by bacteri

Infections and infestations 10040753 Sinusitis

Inflammation (swelling and redness) of the paranasal sinuses,

which may or may not be as a result of infection

Infections and infestation

1004087

Skin infectio

Infection of the ski

Infections and infestation

10065771 Small intestine infectio

Infection of the small bowe

Infections and infestation

1006225

Soft tissue infectio

Infection of soft body tissu

Infections and infestation

1006211

Splenic infectio

Infection of the splee

Infections and infestations 10064505 Stoma site infection

Infection involving a stoma (surgically created opening in th

surface of the body)

Infections and infestation

1004876

Tooth infectio

Infection of the teet

Infections and infestation

1004430

Tracheitis Windpipe infectio

Infections and infestations 10046300 Upper respiratory infection

Infection of the upper respiratory tract (nose, sinuses, throat, wind

pipe, and voice box)

Infections and infestation

1005229

Urethral infectio

Infection of the urethra (tube that drains the bladder

Infections and infestation

10046571 Urinary tract infectio

Urinary tract infectio

Infections and infestation

1006223

Uterine infectio

Infection of the uterus (womb

)

Infections and infestation

1004691

Vaginal infectio

Infections and infestation

1006577

Vulval infectio

Infection of the vulva (external female genitalia

)

Infections and infestation

1004803

Wound infectio

Injury, poisoning and procedural

complications 10002544 Ankle fracture Broken ankle bone

Injury, poisoning and procedural

complications 10002899 Aortic injury

Damage to the aorta (the largest artery [a blood vessel that carries

blood from the heart to the rest of the body] in the body)

Injury, poisoning and procedural

complications 10003162 Arterial injury

Damage to an artery (a blood vessel that carries blood from the

heart to the rest of the body)

Injury, poisoning and procedural

complications 10050458 Biliary anastomotic leak

Leakage of bile from any site in the biliary tree (liver, bile duct,

cystic duct, or gallbladder due) to breakdown of a biliary

anastomosis (surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065802 Bladder anastomotic leak

Leakage from bladder due to breakdown of a bladder anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10006504 Bruising Bruising

Injury, poisoning and procedural

complications 10006634 Burn Burn

Injury, poisoning and procedural

complications 10061103 Dermatitis radiation Redness, flaking or shedding of skin in the radiation treatment area

Injury, poisoning and procedural

complications 10065961 Esophageal anastomotic leak

Leakage

rom the esophagus

(

gullet or the tube that goes

rom

mouth to stomach through which food passes) breakdown of an

esophageal anastomosis (surgical connection of two separate body

structures)

Injury, poisoning and procedural

complications 10016173 Fall Fall

Injury, poisoning and procedural

complications 10065788 Fallopian tube anastomotic leak

Leakage due to breakdown of a fallopian tube (tube between ovar

to uterus [womb]) anastomosis (surgical connection of two separat

body structures)

Injury, poisoning and procedural

complications 10065790 Fallopian tube perforation

Hole in the wall of the fallopian tube (tube between ovary to uteru

[womb])

Injury, poisoning and procedural

complications 10017076 Fracture Broken bone

Injury, poisoning and procedural

complications 10065893 Gastric anastomotic leak

Leakage from stomach due to breakdown of a anastomosis

(surgical connection of two separate body structures)

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Injury, poisoning and procedural

complications 10065879 Gastrointestinal anastomotic leak

Leakage from digestive tract due to breakdown of a anastomosis

(surgical connection of two separate body structures)

Injury, poisoning and procedural

complications 10065712 Gastrointestinal stoma necrosis Death of tissue (necrosis) of the digestive tract

Injury, poisoning and procedural

complications 10020100 Hip fracture Broken hip

Injury, poisoning and procedural

complications 10022161 Injury to carotid artery

Injury to the large blood vessels in the neck that supply blood to th

brain (carotid artery)

Injury, poisoning and procedural

complications 10022213 Injury to inferior vena cava

Damage to the large blood vessel that carries blood to the heart

(inferior vena cava)

Injury, poisoning and procedural

complications 10065849 Injury to jugular vein

Damage to a neck vein that bring deoxygenated blood from the

head back to the heart (jugular vein)

Injury, poisoning and procedural

complications 10022356 Injury to superior vena cava

Damage to the large blood vessel that carries blood from the upper

body to the heart during an operation (superior vena cava)

Injury, poisoning and procedural

complications 10022117

Injury, poisoning and procedural

complications - Other, [add AE here] N/A

Injury, poisoning and procedural

complications 10059095 Intestinal stoma leak

Leakage from ostomy site (a surgically created opening in the

digestive tract for the discharge of body wastes)

Injury, poisoning and procedural

complications 10059094 Intestinal stoma obstruction

Blockage of an ostomy site (a surgically created opening in the

digestive tract for the discharge of body wastes)

Injury, poisoning and procedural

complications 10049468 Intestinal stoma site bleeding

bleeding in an ostomy site (a surgically created opening in th

digestive tract for the discharge of body wastes)

Injury, poisoning and procedural

complications 10065826 Intraoperative arterial injury

Damage to a blood vessel that carries blood from the heart during

surgery

Injury, poisoning and procedural

complications 10065831 Intraoperative breast injury Damage to the breast tissue during surgery

Injury, poisoning and procedural

complications 10065843 Intraoperative cardiac injury Damage to the heart during surgery

Injury, poisoning and procedural

complications 10065844 Intraoperative ear injury Damage to the ear during surgery

Injury, poisoning and procedural

complications 10065834 Intraoperative endocrine injury Damage to the endocrine gland during surgery

Injury, poisoning and procedural

complications 10065825 Intraoperative gastrointestinal injury Damage to the digestive tract during surgery

Injury, poisoning and procedural

complications 10065842 Intraoperative head and neck injury Damage to the head and neck during surgery

Injury, poisoning and procedural

complications 10055298 Intraoperative hemorrhage Uncontrolled bleeding during surgery

Injury, poisoning and procedural

complications 10065827 Intraoperative hepatobiliary injury Damage to the liver during surgery

Injury, poisoning and procedural

complications 10065829 Intraoperative musculoskeletal injury Damage to a muscle during surgery

Injury, poisoning and procedural

complications 10065830 Intraoperative neurological injury Damage to the nervous system during surgery

Injury, poisoning and procedural

complications 10065841 Intraoperative ocular injury Damage to an eye during surgery

Injury, poisoning and procedural

complications 10065845 Intraoperative renal injury Damage to the kidney during surgery

Injury, poisoning and procedural

complications 10065840 Intraoperative reproductive tract injury Damage to the reproductive organs during surgery

Injury, poisoning and procedural

complications 10065832 Intraoperative respiratory injury Damage to the lung during surgery

Injury, poisoning and procedural

complications 10065846 Intraoperative skin injury Damage to the skin during surgery

Injury, poisoning and procedural

complications 10065847 Intraoperative splenic injury Damage to the spleen during surgery

Injury, poisoning and procedural

complications 10065828 Intraoperative urinary injury Damage to the urinary tract during surgery

Injury, poisoning and procedural

complications 10065848 Intraoperative venous injury

Damage to a vein (a blood vessel that carries blood to the heart)

during surgery

Injury, poisoning and procedural

complications 10065803 Kidney anastomotic leak

Leakage from the kidneys due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065891 Large intestinal anastomotic leak

Leakage from the large bowel due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10050457 Pancreatic anastomotic leak

Leakage from the pancreas due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065705 Pharyngeal anastomotic leak

Leakage from the pharynx (throat) due to breakdown of a

anastomosis (surgical connection between two body structures)

Injury, poisoning and procedural

complications 10055322 Postoperative hemorrhage Bleeding after surgery

Injury, poisoning and procedural

complications 10056745

Postoperative thoracic procedure

complication Problem that occurs in the chest cavity as a result of surgery

Injury, poisoning and procedural

complications 10065745 Prolapse of intestinal stoma

Bulge of the ostomy site (a surgically created opening in the

digestive tract for the discharge of body wastes) above the surface

of the belly

Injury, poisoning and procedural

complications 10065822 Prolapse of urostomy Bulge of the stoma (artificial opening) in the urinary system

Injury, poisoning and procedural

complications 10037767 Radiation recall reaction (dermatologic)

Inflammation (swelling and redness) of the skin caused by drugs

after radiation therapy

Injury, poisoning and procedural

complications 10065894 Rectal anastomotic leak

Leakage from the rectum due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10040102 Seroma

Pocket of clear fluid that sometimes develops in the body after

surgery

Injury, poisoning and procedural

complications 10065892 Small intestinal anastomotic leak

Leakage from the small bowel due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065897 Spermatic cord anastomotic leak

Leakage from the spermatic cord (the cord-like structure in males

that run from the abdomen down to each testicle) due to breakdow

of a anastomosis (surgical connection between two body structures)

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Injury, poisoning and procedural

complications 10041569 Spinal fracture Broken bone in the spinal column

Injury, poisoning and procedural

complications 10065898 Stenosis of gastrointestinal stoma

Narrowing of a stoma (a surgically created opening in the digestive

tract for the discharge of body wastes) in the digestive tract

Injury, poisoning and procedural

complications 10042127 Stomal ulcer

Open sore surronding a stoma (a surgically created opening in th

digestive tract for the discharge of body wastes)

Injury, poisoning and procedural

complications 10062548 Tracheal hemorrhage Bleeding in the trachea (windpipe)

Injury, poisoning and procedural

complications 10044291 Tracheal obstruction Blockage of the trachea (windpipe)

Injury, poisoning and procedural

complications 10065749 Tracheostomy site bleeding

bleeding in the site of a surgical procedure to create an opening

through the neck into the trachea (windpipe)

Injury, poisoning and procedural

complications 10065814 Ureteric anastomotic leak

Leakage from the ureter (a tube that carries urine down from the

kidney to the bladder) due to breakdown of a anastomosis (surgical

connection between two body structures)

Injury, poisoning and procedural

complications 10065815 Urethral anastomotic leak

Leakage from the urethra (the tube which connects the bladder t

the outside of the body) due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065882 Urostomy leak

Leakage from urostoma (a stoma [artificial opening] for the urinary

system)

Injury, poisoning and procedural

complications 10065883 Urostomy obstruction

Blockage from a urostoma (a surgically created opening for the

discharge of urine)

Injury, poisoning and procedural

complications 10065748 Urostomy site bleeding

Bleeding in an urostoma (a surgically created opening for th

discharge of urine)

Injury, poisoning and procedural

complications 10065885 Urostomy stenosis

Narrowing of urostoma (a surgically created opening for the

discharge of urine)

Injury, poisoning and procedural

complications 10065886 Uterine anastomotic leak

Leakage from the uterus (womb) due to breakdown of a

anastomosis (surgical connection between two body structures)

Injury, poisoning and procedural

complications 10046810 Uterine perforation Hole in the uterus (womb)

Injury, poisoning and procedural

complications 10065887 Vaginal anastomotic leak

Leakage from the vagina due to breakdown of a anastomosis

(surgical connection between two body structures)

Injury, poisoning and procedural

complications 10065888 Vas deferens anastomotic leak

Leakage

rom the vas de

erens

(

the tube connecting the testes with

the urethra [the tube which connects the bladder to the outside of

the body]) due to breakdown of a anastomosis (surgical connection

between two body structures)

Injury, poisoning and procedural

complications 10062169 Vascular access complication

Problem that occurs when putting in a catheter or gaining access to

a blood vessel

Injury, poisoning and procedural

complications 10047228 Venous injury

Damage to a vein (a blood vessel that carries blood low in oxygen

content from the body back to the heart)

Injury, poisoning and procedural

complications 10053692 Wound complication Problems at the site of an existing wound

Injury, poisoning and procedural

complications 10048031 Wound dehiscence Premature opening of a wound along surgical stitches after surgery

Injury, poisoning and procedural

complications 10048049 Wrist fracture Broken wrist bone

Investigations 10000636

ctivated partial thromboplastin time

prolonged Test that shows a problem in blood clotting

Investigation

10001551

lanine aminotransferase increase

Increased blood level of a liver enzyme (ALT/SGPT

)

Investigations 10001675 Alkaline phosphatase increased

Increased blood level of a liver or bone enzyme (alkaline

phosphatase)

Investigation

10003481

spartate aminotransferase increase

Increased blood level of a liver enzyme (AST/SGOT

)

Investigations 10005332 Blood antidiuretic hormone abnormal

bnomal level of antidiuretic hormone (a hormone that regulates th

body's retention of water)

Investigations 10005364 Blood bilirubin increased

Increased blood level of a liver pigment (bilirubin) often a sign o

liver problems

Investigations 10005452 Blood corticotrophin decreased

Decreased blood level of corticotrophin (a hormone produced b

the pituitary gland)

Investigations 10005561 Blood gonadotrophin abnormal

Abnormal blood level of gonadotrophin (any hormone that

stimulates the gonads [the organs that produce sperm or eggs])

Investigations 10005778 Blood prolactin abnormal

bnormal blood level of prolactin (a hormone secreted by the

pituitary gland that stimulates milk production)

Investigations 10065906

Carbon monoxide diffusing capacity

decreased Decreased ability of the lung to absorb carbon monoxide

Investigations 10007612 Cardiac troponin I increased

Increased blood level of a heart muscle protein (troponin I)

indicating damage to the heart muscle

Investigations 10007613 Cardiac troponin T increased

Increased blood level of a heart muscle protein (troponin T)

indicating damage to the heart muscle

Investigation

1000783

CD4 lymphocytes decrease

Decreased number of a type of white blood cell (lymphocyte

Investigation

10008661 Cholesterol hig

Increased blood level of cholestero

Investigations 10011268 CPK increased

Increased blood level of enzyme (creatine phosphokinase) from

muscle

Investigations 10011368 Creatinine increased

Increased blood level of creatinine (a substance normally eliminate

by the kidneys into the urine)

Investigations 10050528 Ejection fraction decreased

decrease in the amount of blood pumped (ejected) by the lowe

chamber (ventricle) of the heart

Investigations 10014383

Electrocardiogram QT corrected interval

prolonged Abnormal electrical conduction within the heart

Investigation

1001659

Fibrinogen decrease

Decreased level of a blood protein needed for blood clottin

Investigations 10016987 Forced expiratory volume decreased

Decreased volume of air that is exhaled in a specific time period

indicative of lung function

Investigation

1005691

GGT increased Increased blood level of a liver enzyme (GGT

)

Investigation

1001874

Growth hormone abnorma

bnormal level of growth hormon

Investigations 10019150 Haptoglobin decreased

Decrease of a blood protein called haptoglobin which shows tha

red blood cells are being destroyed

Investigations 10055599 Hemoglobin increased

Decrease of a red blood cell protein (hemoglobin) that carries

oxygen in the body

Investigations 10022402 INR increased

Increased INR (measure of the ability of the blood to clot properly)

which increases the risk of bleeding

Investigation

1002457

Lipase increase

Increased blood level of fat-digesting enzyme (lipase

)

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Investigation

1002525

Lymphocyte count decrease

Decreased number of a type of white blood cell (lymphocyte

Investigation

1002525

Lymphocyte count increase

Increased number of a type of white blood cell (lymphocyte

Investigations 10029366 Neutrophil count decreased

Decreased number of a type of white blood cell

(neutrophil/granulocyte)

Investigations 10062646 Pancreatic enzymes decreased Decreased levels of pancreatic enzymes in a biological specimen

Investigations 10035528 Platelet count decreased

Decreased number of a type of blood cell that helps to clot blood

(platelet)

Investigation

1004013

Serum amylase increase

Increased blood level of a digestive enzyme (amylase

)

Investigation

1005989

Urine output decrease

bnormally low urine outpu

Investigations 10047580 Vital capacity abnormal

bnormal amount of air that is exhaled by following a maxima

inhalation

Investigation

1004789

Weight gain Weight gain

Investigation

1004790

Weight loss Weight loss

Investigation

1004918

White blood cell decrease

Decrease in the total number of white blood cells (leukocytes

Metabolism and nutrition disorder

1000048

cidosis More acid than normal in the bloo

Metabolism and nutrition disorders 10001598 Alcohol intolerance

Unwanted reaction to drinking alcohol, which can include stuff

nose, skin reddening, abnormal heart rhythm, nausea, vomiting,

indigestion and headaches

Metabolism and nutrition disorder

1000168

lkalosi

Less acid than normal in the bloo

Metabolism and nutrition disorder

1000264

norexi

Loss of appetit

Metabolism and nutrition disorders 10012174 Dehydration

Dehydration (when your body does not have as much water an

fluid as it should)

Metabolism and nutrition disorder

1005242

Glucose intoleranc

bnormal control of blood sugar leve

Metabolism and nutrition disorder

1002058

Hypercalcemi

Increased blood level of calciu

Metabolism and nutrition disorder

1002063

Hyperglycemi

Increased blood sugar leve

Metabolism and nutrition disorder

1002064

Hyperkalemi

Increased blood level of potassiu

Metabolism and nutrition disorder

1002067

Hypermagnesemi

Increased blood level of magnesiu

Metabolism and nutrition disorder

1002068

Hypernatremi

Increased blood level of sodiu

Metabolism and nutrition disorder

1002087

Hypertriglyceridemi

Increased blood level of a form of fat called triglycerid

Metabolism and nutrition disorders 10020907 Hyperuricemia

Increased blood level of uric acid, a waste material from food

digestion

Metabolism and nutrition disorder

1002094

Hypoalbuminemi

Decreased levels of a blood protein called albumi

Metabolism and nutrition disorder

1002094

Hypocalcemi

Decreased blood level of calciu

Metabolism and nutrition disorder

1002100

Hypoglycemi

Decreased blood sugar leve

Metabolism and nutrition disorder

1002101

Hypokalemi

Decreased blood level of potassium

Metabolism and nutrition disorder

1002102

Hypomagnesemi

Decreased blood level of magnesiu

Metabolism and nutrition disorder

1002103

Hyponatremi

Decreased blood level of sodiu

Metabolism and nutrition disorder

1002105

Hypophosphatemi

Decreased blood level of phosphat

Metabolism and nutrition disorder

1006597

Iron overload Increased amount of iron build-up in the body tissue

Metabolism and nutrition disorders 10027433

Metabolism and nutrition disorders - Other,

[add AE here] N/A

Metabolism and nutrition disorders 10029883 Obesity

Overweight by 20% or more of your ideal body weight/height ratio.

Also having a high amount of body fat.

Metabolism and nutrition disorders 10045152 Tumor lysis syndrome

Group of signs and symptoms due to rapid breakdown of tumor tha

can occur after treatment of cancer has started that causes

increased levels of blood potassium, uric acid, and phosphate,

decreased levels of blood calcium, and kidney failure

Musculoskeletal and connective tissue

disorders 10065775 Abdominal soft tissue necrosis Death of tissue of the belly wall

Musculoskeletal and connective tissue

disorders 10003239 Arthralgia Joint pain

Musculoskeletal and connective tissue

disorders 10003246 Arthritis Inflammation (swelling and redness) in a joint (arthritis)

Musculoskeletal and connective tissue

disorders 10066480 Avascular necrosis

Temporary or permanent loss of the blood supply to an area o

bone resulting in the death of bone tissue

Musculoskeletal and connective tissue

disorders 10003988 Back pain Back pain

Musculoskeletal and connective tissue

disorders 10006002 Bone pain Bone pain

Musculoskeletal and connective tissue

disorders 10048677 Buttock pain Buttock pain

Musculoskeletal and connective tissue

disorders 10008496 Chest wall pain Chest wall pain

Musculoskeletal and connective tissue

disorders 10015688 Exostosis Non-cancerous overgrowth of new bone on the surface of a bone

Musculoskeletal and connective tissue

disorders 10065799 Fibrosis deep connective tissue

Scar or thickening of the layer below the superficial fat and include

muscle and all connective tissue down to bone

Musculoskeletal and connective tissue

disorders 10016750 Flank pain

Pain in the area on the side of the body in the region below the rib

and above the hip

Musculoskeletal and connective tissue

disorders 10062572 Generalized muscle weakness Muscle weakness of the whole body

Musculoskeletal and connective tissue

disorders 10018761 Growth suppression

Height that is smaller than normal as expected for the age of a

person

Musculoskeletal and connective tissue

disorders 10065779 Head soft tissue necrosis Death of soft tissue of the head

Musculoskeletal and connective tissue

disorders 10023215 Joint effusion Excess fluid in a joint

Musculoskeletal and connective tissue

disorders 10048706 Joint range of motion decreased Joint stiffness

Musculoskeletal and connective tissue

disorders 10065796

Joint range of motion decreased cervical

spine Stiff neck

Musculoskeletal and connective tissue

disorders 10065800

Joint range of motion decreased lumbar

spine Stiff lower back

Musculoskeletal and connective tissue

disorders 10023509 Kyphosis

bnormally increased outward curving of the spine at the level o

the ribs that causes a bowing of the back, which leads to a

hunchback or slouching posture

Musculoskeletal and connective tissue

disorders 10024842 Lordosis

bnormally increased inward curve of the lumbar spine (just abov

the buttocks)

Musculoskeletal and connective tissue

disorders 10065780 Muscle weakness left-sided Muscle weakness of the left side of the body

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Musculoskeletal and connective tissue

disorders 10065776 Muscle weakness lower limb Muscle weakness of legs

Musculoskeletal and connective tissue

disorders 10065794 Muscle weakness right-sided Muscle weakness of the right side of the body

Musculoskeletal and connective tissue

disorders 10065795 Muscle weakness trunk Muscle weakness of the trunk of the body

Musculoskeletal and connective tissue

disorders 10065895 Muscle weakness upper limb Muscle weakness of arms

Musculoskeletal and connective tissue

disorders 10028395

Musculoskeletal and connective tissue

disorder - Other, [add AE here] N/A

Musculoskeletal and connective tissue

disorders 10065783 Musculoskeletal deformity

Deformity of the musculoskeletal system (relating to muscles and

the skeleton)

Musculoskeletal and connective tissue

disorders 10028411 Myalgia Muscle pain

Musculoskeletal and connective tissue

disorders 10028653 Myositis Inflammation (swelling and redness) of the muscles

Musculoskeletal and connective tissue

disorders 10028836 Neck pain Neck pain

Musculoskeletal and connective tissue

disorders 10065781 Neck soft tissue necrosis Death of soft tissue of the neck

Musculoskeletal and connective tissue

disorders 10064658 Osteonecrosis of jaw Destruction or death of jawbone

Musculoskeletal and connective tissue

disorders 10031282 Osteoporosis Bone thinning

Musculoskeletal and connective tissue

disorders 10033425 Pain in extremity Leg and/or arm pain

Musculoskeletal and connective tissue

disorders 10065793 Pelvic soft tissue necrosis Death of soft tissue of the pelvis (hips)

Musculoskeletal and connective tissue

disorders 10039722 Scoliosis Abnormal side-to-side curvature of the spine

Musculoskeletal and connective tissue

disorders 10065777 Soft tissue necrosis lower limb Death of soft tissue of the legs

Musculoskeletal and connective tissue

disorders 10065778 Soft tissue necrosis upper limb Death of soft tissue of the arms

Musculoskeletal and connective tissue

disorders 10065798 Superficial soft tissue fibrosis Degeneration of the superficial soft tissue

Musculoskeletal and connective tissue

disorders 10044684 Trismus Difficulty or limitation in ability to open mouth

Musculoskeletal and connective tissue

disorders 10065738 Unequal limb length Difference between the lengths of the arms and/or legs

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) 10048293

Leukemia secondary to oncology

chemotherapy A blood disease (leukemia) caused by chemotherapy

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) 10028533 Myelodysplastic syndrome Decreased production of blood cells by the bone marrow

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) 10029104

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) - Other,

[add AE here] N/A

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) 10049737 Treatment related secondary malignancy

Development of a new cancer resulting from treatment of an earlier

cancer

Neoplasms benign, malignant and

unspecified (incl cysts and polyps) 10045158 Tumor pain Pain in the area of the tumor

Nervous system disorders 10053662 Abducens nerve disorder

bnormal function of the nerve responsible for moving the eye t

the side

Nervous system disorders 10060929 Accessory nerve disorder

bnormal function of the nerve responsible for movement of the

shoulders and turning of the head

Nervous system disorders 10000521 Acoustic nerve disorder NOS Abnormal function of the nerve responsible for hearing and balance

Nervous system disorders 10001540 Akathisia

Uncomfortable feeling of inner restlessness and a compelling need

to be in constant motion

Nervous system disorders 1000194

mnesia Memory los

Nervous system disorders 1000295

phoni

Inability to spea

Nervous system disorders 10003074 Arachnoiditis

Inflammation (swelling and redness) of the arachnoid membran

(one of the membranes that surround and protect the nerves of the

central nervous system, including the brain and spinal cord)

Nervous system disorders 10003591 Ataxia

Loss of muscle coordination; awkward, uncoordinated walking;

unsteadiness when walking

Nervous system disorders 10065417 Brachial plexopathy Decreased movement or sensation in the arm due to nerve problem

Nervous system disorders 1006578

Central nervous system necrosi

Destruction or death of tissue of the brain and/or spinal cor

Nervous system disorders 10008164 Cerebrospinal fluid leakage

Leak of cerebrospinal fluid (fluid that surrounds the brain and spina

cord)

Nervous system disorders 1000984

Cognitive disturbanc

Major change in thinking pattern

Nervous system disorders 1001025

Concentration impairmen

Decreased ability to concentrat

Nervous system disorders 1001237

Depressed level of consciousnes

Sleepines

Nervous system disorders 10013573 Dizziness

Dizziness (or sensation of lightheadedness, unsteadiness, o

giddiness)

Nervous system disorders 10013887 Dysarthria

Slow and slurred speech resulting from a lack of control of the

muscles used in speech

Nervous system disorders 1006287

Dysesthesi

bnormal unpleasant sensatio

Nervous system disorders 10013911 Dysgeusi

Taste changes

Nervous system disorders 10013951 Dysphasi

Speech problem

Nervous system disorders 1001421

Edema cerebral Swelling in the brai

Nervous system disorders 1001462

Encephalopath

bnormal brain functio

Nervous system disorders 1001583

Extrapyramidal disorde

Restless, repetitive, or involuntary movements and rapid speec

Nervous system disorders 1005127

Facial muscle weaknes

Weakness of facial muscles

Nervous system disorders 10061457 Facial nerve disorder

bnormal function of the nerve that controls facial expressio

Nervous system disorders 10061185 Glossopharyngeal nerve disorder Abnormal function of the nerve responsible for swallowing and taste

Nervous system disorders 10019211 Headach

Headache or head pai

Nervous system disorders 1002050

Hydrocephalu

Excess fluid in brai

Nervous system disorders 1002076

Hypersomni

Excessive sleepiness during the daytim

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Nervous system disorders 10061212 Hypoglossal nerve disorder

bnormal function of the nerve that is responsible for movement o

the tongue

Nervous system disorders 1002276

Intracranial hemorrhag

Bleeding in the brai

Nervous system disorders 1002303

Ischemia cerebrovascula

Stroke caused by decreased blood flow to the brai

Nervous system disorders 10065836 IVth nerve disorder

bnormal function of the nerve that is responsible for eyelid

movement

Nervous system disorders 10024264 Lethargy Abnormal drowsiness or sluggishness, an unusual lack of energy

Nervous system disorders 10024382 Leukoencephalopathy

Progressive necrosis (tissue death) of a part (the white matter) of

the brain without inflammation (swelling and redness)

Nervous system disorders 1002717

Memory impairmen

Trouble with memor

Nervous system disorders 10027198 Meningismus

Condition resulting in stiff neck, sensitivity to light, and headach

caused by inflammation (swelling and redness) of the linings of the

brain

Nervous system disorders 10028041 Movements involuntar

Involuntary movement

Nervous system disorders 1002852

Myeliti

Inflammation (swelling and redness) of the spinal cor

Nervous system disorders 10029205

Nervous system disorders - Other, [add AE

here] N/A

Nervous system disorders 1002922

Neuralgi

Nerve pain

Nervous system disorders 1002986

Nystagmus Rapid, jerky involuntary movements of the ey

Nervous system disorders 10053661 Oculomotor nerve disorder

bnormal function of the nerve that is responsible for eyelid

movement and for controling the size of the pupil

Nervous system disorders 1005638

Olfactory nerve disorde

bnormal function of the nerve responsible for smel

Nervous system disorders 10033987 Paresthesia

Commonly known as "pins and needles," where part of the bod

(typically a foot or hand) begins to tingle and becomes numb, or

"falls asleep"

Nervous system disorders 10034580 Peripheral motor neuropathy

Weakness or paralysis (loss of muscle function) caused by damage

to peripheral nerves (those nerves outside of brain and spinal cord)

Nervous system disorders 10034620 Peripheral sensory neuropathy

Inflammation (swelling and redness) or degeneration of the

peripheral nerves (those nerves outside of brain and spinal cord)

causing numbness, tingling, burning

Nervous system disorders 1005623

Phantom pai

Pain in a limb or organ that has been amputated

Nervous system disorders 10036653 Presyncope

Episode of near-fainting which may include lightheadedness

dizziness, severe weakness, blurred vision, which may come befor

a fainting episode

Nervous system disorders 10063636 Pyramidal tract syndrome

bnormal function of nerves in the brain and spine which contro

muscles of voluntary movement

Nervous system disorders 10061928 Radiculitis

Inflammation (swelling and redness) involving a nerve root (the

initial segment of a nerve leaving the central nervous system)

Nervous system disorders 10038130 Recurrent laryngeal nerve palsy

Paralysis

(

loss o

muscle

unction

)

the recurrent laryngeal nerve

(a branch of a nerve that supplies the heart, trachea (windpipe) and

esophagus (gullet or the tube that goes from mouth to stomach

through which food passes)

Nervous system disorders 10063761

Reversible posterior leukoencephalopathy

syndrome

bnormal changes in the brain that can cause a collection o

symptoms including headache, confusion, seizures, and vision loss

associated with MRI imaging findings (RPLS)

Nervous system disorders 1003990

Seizur

Convulsion or seizur

Nervous system disorders 1004074

Sinus pai

Pain in the sinuse

Nervous system disorders 1004134

Somnolenc

Sleepiness, the state of feeling drowsy, ready to fall aslee

Nervous system disorders 10041416 Spasticity

Continual tightening and contraction of certain muscles resulting i

problems walking and talking

Nervous system disorders 1004224

Stroke Stoppage of blood flow to your brai

Nervous system disorders 1004277

Syncop

Faintin

Nervous system disorders 10044391 Transient ischemic attacks

Stroke that comes and goes quickly (a mini stroke) with no lasting

effects. They can be a warning of future stroke.

Nervous system disorders 10044565 Tremor

Uncontrolled trembling or shaking movements in one or more parts

of your body

Nervous system disorders 10060890 Trigeminal nerve disorder

bnormal function of the nerve responsible for feeling in the fac

and control of the muscles for chewing

Nervous system disorders 10061403 Vagus nerve disorder

bnormal function of the nerve that serves the gut, heart, and voice

box

Nervous system disorders 1004716

Vasovagal reactio

Sudden drop in blood pressure that may cause faintin

Pregnancy, puerperium and perinatal

conditions 10016479 Fetal death Death of fetus before delivery

Pregnancy, puerperium and perinatal

conditions 10054746 Fetal growth retardation

Inhibition of fetal growth resulting in the inability of the fetus t

achieve its potential weight

Pregnancy, puerperium and perinatal

conditions 10036585

Pregnancy, puerperium and perinatal

conditions - Other, [add AE here] N/A

Pregnancy, puerperium and perinatal

conditions 10036595 Premature delivery

Birth before the 9th month of pregnancy (the normal length o

pregnancy)

Pregnancy, puerperium and perinatal

conditions 10045542 Unintended pregnancy Unexpected pregnancy

Psychiatric disorder

1000149

gitation

gitation or restlessnes

Psychiatric disorder

1000265

norgasmia Inability to achieve orgasm (climax

)

Psychiatric disorder

1000285

nxiet

nxiety, feelings of dread or dange

Psychiatric disorder

1001030

Confusio

Psychiatric disorder

1005706

Delayed orgasm Delay in orgasm (climax

)

Psychiatric disorders 10012218 Delirium

Sudden severe confusion and rapid changes in brain function tha

occur with physical or mental illness

Psychiatric disorders 10012260 Delusions

Beliefs which persist despite clear evidence that they are actuall

false

Psychiatric disorders 10012378 Depression

Feelings of sadness, worthlessness, thoughts of suicide or death

(depression)

Psychiatric disorder

1001553

Euphori

Exaggerated feeling of well bein

Psychiatric disorders 10019077 Hallucinations

Seeing or sensing things that aren't there while a person is awak

and conscious (such as hearing voices)

Psychiatric disorder

1002243

Insomni

Difficulty sleeping or falling aslee

Psychiatric disorder

1002441

Libido decrease

Decreased sexual desir

Psychiatric disorder

10024421 Libido increase

Increased sexual desir

Psychiatric disorders 10026749 Mania

Extremely elevated mood, energy, unusual thought patterns, an

sometimes psychosis (mental state often described as involving a

"loss of contact with reality")

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Psychiatric disorders 10034719 Personality change Noticible changes in a persons personality, behavior, and thinking

Psychiatric disorders 10037175 Psychiatric disorders - Other, [add AE here] N/A

Psychiatric disorders 10037234 Psychosis

Mental illness often described as involving a "loss of contact with

reality" which can be associated with bipolar disorder (manic-

depressive) or brain tumor

Psychiatric disorder

1003874

Restlessness Inability to sit still, relax, or res

Psychiatric disorder

1004245

Suicidal ideatio

Thoughts of taking ones own lif

Psychiatric disorder

1004246

Suicide attemp

Trying to takes ones own lif

Renal and urinary disorder

1006933

cute kidney injur

Sudden decrease of kidney functio

Renal and urinary disorder

1006357

Bladder perforatio

Hole in the bladde

Renal and urinary disorder

1004899

Bladder spasm Sudden and involuntary contraction of the bladde

Renal and urinary disorder

1006484

Chronic kidney diseas

Gradual (and usually permanent) loss of kidney functio

Renal and urinary disorders 10063057 Cystitis noninfective

Inflammation (swelling and redness) of the bladder not due t

urinary tract infection

Renal and urinary disorder

1001945

Hematuri

Blood in the urin

Renal and urinary disorders 10019489 Hemoglobinuria

Presence of free hemoglobin (the blood protein that carries oxygen

)

in the urine

Renal and urinary disorders 10037032 Proteinuria

More protein leaking into the urine than usual, often a sign of kidne

disease

Renal and urinary disorders 10038359

Renal and urinary disorders - Other, [add

AE here] N/A

Renal and urinary disorders 10038385 Renal calculi Formation of crystals in the kidney. Also known as kidney stones.

Renal and urinary disorder

1003841

Renal coli

Type of short and frequent severe pain in the flank (side

Renal and urinary disorder

1003846

Renal hemorrhag

Bleeding in the kidne

Renal and urinary disorders 10065368 Urinary fistula

bnormal hole between part of the urinary system and anothe

organ or tissue

Renal and urinary disorder

1004653

Urinary frequenc

Need to urinate ofte

Renal and urinary disorder

1004654

Urinary incontinenc

Inability to control the flow of urine from the bladde

Renal and urinary disorder

1004655

Urinary retentio

Difficulty emptying the bladde

Renal and urinary disorder

1006157

Urinary tract obstructio

Blockage of the normal flow of contents of the urinary trac

Renal and urinary disorder

1006222

Urinary tract pai

Pain of the urinary trac

Renal and urinary disorder

1004659

Urinary urgenc

Increased need to urinat

Renal and urinary disorder

1004662

Urine discoloratio

Change in color of the urin

Reproductive system and breast disorders 10003883 Azoospermia Complete absence of sperm in semen

Reproductive system and breast disorders 10006179 Breast atrophy Underdevelopment of the breast

Reproductive system and breast disorders 10006298 Breast pain Breast pain

Reproductive system and breast disorders 10013934 Dysmenorrhea Severe abdominal cramps duing a women's period

Reproductive system and breast disorders 10013941 Dyspareunia Painful sexual intercourse

Reproductive system and breast disorders 10014326 Ejaculation disorder Problems related to ejaculation

Reproductive system and breast disorders 10061461 Erectile dysfunction

Impotence or the inability to have or maintain an erection durin

sexual intercourse

Reproductive system and breast disorders 10065789 Fallopian tube obstruction Blockage of Fallopian tube (tube between ovary to uterus [womb])

Reproductive system and breast disorders 10065791 Fallopian tube stenosis Narrowing of Fallopian tube (tube between ovary to uterus [womb])

Reproductive system and breast disorders 10061149 Female genital tract fistula Hole between a female reproductive organ and another organ

Reproductive system and breast disorders 10054382 Feminization acquired Development of female physical characteristics in males

Reproductive system and breast disorders 10018146 Genital edema Swelling in the genitals

Reproductive system and breast disorders 10018801 Gynecomastia Enlarged breasts in males

Reproductive system and breast disorders 10060602 Hematosalpinx

Presence of blood in a fallopian tube (tube between ovary to uteru

[womb])

Reproductive system and breast disorders 10022992 Irregular menstruation Irregular menstrual periods

Reproductive system and breast disorders 10061261 Lactation disorder Change in ability to produce breast milk

Reproductive system and breast disorders 10027313 Menorrhagia Abnormally heavy bleeding during a women's period

Reproductive system and breast disorders 10065823 Nipple deformity Deformed nipple

Reproductive system and breast disorders 10030300 Oligospermia Decreased number of sperm in semen

Reproductive system and breast disorders 10065763 Ovarian hemorrhage Bleeding in the ovary

Reproductive system and breast disorders 10033279 Ovarian rupture Tearing or disruption of the ovarian tissue

Reproductive system and breast disorders 10033314 Ovulation pain

n on one s

e o

e a

omen

)

aroun

me o

ovulation

Reproductive system and breast disorders 10064026 Pelvic floor muscle weakness

Weakness in the “pelvic floor” (the group of muscles that form a

sling or hammock across the opening of a woman’s pelvis)

Reproductive system and breast disorders 10034263 Pelvic pain Pain in the pelvic area

Reproductive system and breast disorders 10034310 Penile pain Pain in the penis

Reproductive system and breast disorders 10061339 Perineal pain

Pain in the perineum (the area between the anus and the rear par

of the external genitalia)

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Reproductive system and breast disorders 10036601 Premature menopause Menopause before the age of 40

Reproductive system and breast disorders 10055325 Prostatic hemorrhage Bleeding in the prostate

Reproductive system and breast disorders 10055026 Prostatic obstruction Blockage of the prostate

Reproductive system and breast disorders 10036968 Prostatic pain Pain in the prostate

Reproductive system and breast disorders 10039757 Scrotal pain Pain of the scrotum or its contents (testes)

Reproductive system and breast disorders 10065762 Spermatic cord hemorrhage

Bleeding in the spermatic cord

(

a structure resembling a cord that

suspends the testis within the scrotum and contains the vas

deferens [the tube that carries sperm] and other vessels and

nerves)

Reproductive system and breast disorders 10065805 Spermatic cord obstruction

Blockage o

the spermatic cord

(

a structure resembling a cord that

suspends the testis within the scrotum and contains the vas

deferens [the tube that carries sperm] and other vessels and

nerves)

Reproductive system and breast disorders 10043306 Testicular disorder Abnormality of the testis

Reproductive system and breast disorders 10055347 Testicular hemorrhage Bleeding in the testis

Reproductive system and breast disorders 10043345 Testicular pain Pain in the testis

Reproductive system and breast disorders 10065811 Uterine fistula Hole between uterus (womb) and another organ

Reproductive system and breast disorders 10046789 Uterine hemorrhage Bleeding in the uterus (womb)

Reproductive system and breast disorders 10065928 Uterine obstruction Blockage of uterus (womb)

Reproductive system and breast disorders 10046809 Uterine pain Pain in the uterus (womb)

Reproductive system and breast disorders 10046901 Vaginal discharge Secretion from the vagina

Reproductive system and breast disorders 10046904 Vaginal dryness Vaginal dryness causing itching and/or burning sensation

Reproductive system and breast disorders 10065813 Vaginal fistula Abnormal hole between the vagina and another organ or tissue

Reproductive system and breast disorders 10046912 Vaginal hemorrhage Bleeding in the vagina

Reproductive system and breast disorders 10046916 Vaginal inflammation Inflammation (swelling and redness) of the vagina

Reproductive system and breast disorders 10065817 Vaginal obstruction Blockage of the vagina

Reproductive system and breast disorders 10046937 Vaginal pain Pain in the vagina

Reproductive system and breast disorders 10065818 Vaginal perforation Hole in the vaginal wall

Reproductive system and breast disorders 10053496 Vaginal stricture Narrowing of a tube or passage in the vagina

Reproductive system and breast disorders 10046947 Vaginismus

Involuntary spasms o

the pelvic

loor muscles

(

the group o

muscles that form a sling or hammock across the opening of a

woman’s pelvis) resulting in tightness of the vaginal wall during

penetration such as during sexual intercourse

Respiratory, thoracic and mediastinal

disorders 10001409 Adult respiratory distress syndrome

Severe potentially life-threatening damage to the lungs which ca

lead to fluid in the lungs

Respiratory, thoracic and mediastinal

disorders 10001723 Allergic rhinitis Stuffy or runny nose, sneezing

Respiratory, thoracic and mediastinal

disorders 10002972 Apnea Stopping of breathing

Respiratory, thoracic and mediastinal

disorders 10003504 Aspiration Breathing in of solids or liquids into the lungs

Respiratory, thoracic and mediastinal

disorders 10003598 Atelectasis Partial lung collapse

Respiratory, thoracic and mediastinal

disorders 10006437 Bronchial fistula

Hole between the bronchus (an air tube from the windpipe to th

lungs) and another organ

Respiratory, thoracic and mediastinal

disorders 10006440 Bronchial obstruction

Blockage of the bronchus (an air tube from the windpipe to th

lungs)

Respiratory, thoracic and mediastinal

disorders 10063524 Bronchial stricture

Narrowing of the bronchus (an air tube from the windpipe to th

lungs)

Respiratory, thoracic and mediastinal

disorders 10053481 Bronchopleural fistula

bnormal hole between the lower breathing tube and the bod

cavity that surrounds the lungs

Respiratory, thoracic and mediastinal

disorders 10065746 Bronchopulmonary hemorrhage Bleeding from the lungs

Respiratory, thoracic and mediastinal

disorders 10006482 Bronchospasm

Sudden constriction of the small airways of the lung that can caus

wheezing and shortness of breath

Respiratory, thoracic and mediastinal

disorders 10051228 Chylothorax

Type of pleural effusion (excess fluid in the pleural cavity [(the bod

cavity that surrounds the lungs])

Respiratory, thoracic and mediastinal

disorders 10011224 Cough Cough

Respiratory, thoracic and mediastinal

disorders 10013963 Dyspnea Shortness of breath

Respiratory, thoracic and mediastinal

disorders 10015090 Epistaxis Nose bleed

Respiratory, thoracic and mediastinal

disorders 10020039 Hiccups Hiccups

Respiratory, thoracic and mediastinal

disorders 10020201 Hoarseness Hoarseness

Respiratory, thoracic and mediastinal

disorders 10021143 Hypoxia Decrease in the oxygen supply to a tissue

Respiratory, thoracic and mediastinal

disorders 10023838 Laryngeal edema Swelling of the voice box

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Respiratory, thoracic and mediastinal

disorders 10065786 Laryngeal fistula Hole between the voice box and another organ

Respiratory, thoracic and mediastinal

disorders 10065759 Laryngeal hemorrhage Bleeding in the voice box

Respiratory, thoracic and mediastinal

disorders 10065735 Laryngeal inflammation Swelling and redness involving the voice box

Respiratory, thoracic and mediastinal

disorders 10065880 Laryngeal mucositis Irritation or sores in the lining of the voice box

Respiratory, thoracic and mediastinal

disorders 10059639 Laryngeal obstruction Blockage of or in the voice box

Respiratory, thoracic and mediastinal

disorders 10023862 Laryngeal stenosis Narrowing of the voice box

Respiratory, thoracic and mediastinal

disorders 10062667 Laryngopharyngeal dysesthesia Uncomfortable feeling of tightness of of choaking in the throat

Respiratory, thoracic and mediastinal

disorders 10023891 Laryngospasm Uncontrolled contractions of the muscles of the vocal cords

Respiratory, thoracic and mediastinal

disorders 10056356 Mediastinal hemorrhage

Bleeding in the central area of the chest

Respiratory, thoracic and mediastinal

disorders 10028735 Nasal congestion Stuffy nose

Respiratory, thoracic and mediastinal

disorders 10034825 Pharyngeal fistula Hole between the throat and another organ

Respiratory, thoracic and mediastinal

disorders 10055315 Pharyngeal hemorrhage Bleeding in the throat

Respiratory, thoracic and mediastinal

disorders 10065881 Pharyngeal mucositis Irritation or sores in the lining of the throat

Respiratory, thoracic and mediastinal

disorders 10065706 Pharyngeal necrosis Death of tissue in the throat

Respiratory, thoracic and mediastinal

disorders 10050028 Pharyngeal stenosis Narrowing of the throat

Respiratory, thoracic and mediastinal

disorders 10034844 Pharyngolaryngeal pain Throat pain

Respiratory, thoracic and mediastinal

disorders 10035598 Pleural effusion

Build up of a large amount of fluid between the layers of tissue tha

line the lungs and chest cavity

Respiratory, thoracic and mediastinal

disorders 10055319 Pleural hemorrhage Bleeding in the lining of the chest cavity and/or lungs

Respiratory, thoracic and mediastinal

disorders 10035623 Pleuritic pain Pain in the lining of the chest cavity and/or lungs

Respiratory, thoracic and mediastinal

disorders 10035742 Pneumonitis

Inflammation of the lungs that may cause difficulty breathing an

can be life-threatening

Respiratory, thoracic and mediastinal

disorders 10035759 Pneumothorax

ccumulation of air in the pleural cavity (the space that surround

the lungs) causing the lung to collapse

Respiratory, thoracic and mediastinal

disorders 10036402 Postnasal drip Excess fluid dripping in the back of the throat and/or the nose

Respiratory, thoracic and mediastinal

disorders 10036790 Productive cough Cough that brings up mucus (phlegm)

Respiratory, thoracic and mediastinal

disorders 10037375 Pulmonary edema Abnormal build up of fluid in the lungs

Respiratory, thoracic and mediastinal

disorders 10037383 Pulmonary fibrosis

Scarring of the lungs that can cause shortness of breath and

interfere with breathing

Respiratory, thoracic and mediastinal

disorders 10065873 Pulmonary fistula Hole between the lungs and some other organ

Respiratory, thoracic and mediastinal

disorders 10037400 Pulmonary hypertension High blood pressure of the blood vessels in the lungs

Respiratory, thoracic and mediastinal

disorders 10038695 Respiratory failure

Failure of the lungs (respiratory system) to perform it's function of

taking in oxygen and giving off carbon dioxide

Respiratory, thoracic and mediastinal

disorders 10038738

Respiratory, thoracic and mediastinal

disorders - Other, [add AE here] N/A

Respiratory, thoracic and mediastinal

disorders 10038921 Retinoic acid syndrome

collection o

symptoms including

ever, di

iculty breathing, ches

pain, fluid in the lung (seen on chest X-ray), fluid around the lungs

and heart, and lack of oxygen first seen in patients receiving the

drug retinoic acid

Respiratory, thoracic and mediastinal

disorders 10062244 Sinus disorder Problem of the sinuses

Respiratory, thoracic and mediastinal

disorders 10040975 Sleep apnea Stoppage of breathing for short periods while sleeping

Respiratory, thoracic and mediastinal

disorders 10041232 Sneezing Sneezing

Respiratory, thoracic and mediastinal

disorders 10041367 Sore throat Sore throat

Respiratory, thoracic and mediastinal

disorders 10042241 Stridor

bnormal, high-pitched, musical breathing sound caused by

blockage in the throat or voice box

Respiratory, thoracic and mediastinal

disorders 10065787 Tracheal fistula Hole between the windpipe and another organ

Respiratory, thoracic and mediastinal

disorders 10065900 Tracheal mucositis Irritation or sores in the lining of the windpipe

Respiratory, thoracic and mediastinal

disorders 10050816 Tracheal stenosis Narrowing of the windpipe

Respiratory, thoracic and mediastinal

disorders 10047681 Voice alteration Voice change

Respiratory, thoracic and mediastinal

disorders 10047924 Wheezing

High-pitched whistling sound during breathing caused narrowing o

the breathing tubes

Skin and subcutaneous tissue disorder

1000176

lopeci

Hair loss

Skin and subcutaneous tissue disorder

10005901 Body odo

Body odo

Skin and subcutaneous tissue disorder

1000655

Bullous dermatiti

Skin condition with fluid-filled blister

Skin and subcutaneous tissue disorder

1001378

Dry skin Dry skin

Skin and subcutaneous tissue disorders 10015218 Erythema multiforme

Severe reaction of the skin and gut lining that may include rash an

shedding or death of tissue

Skin and subcutaneous tissue disorders 10015277 Erythroderma Generalized reddening and flaking of most of the skin of the body

Skin and subcutaneous tissue disorder

10016241 Fat atroph

Shrinking of body fa

Skin and subcutaneous tissue disorders 10020112 Hirsutism

Excess body hair in women where normally not present (such a

beard, moustache, chest, or stomach hair)

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Skin and subcutaneous tissue disorder

1002064

Hyperhidrosi

Excess sweating

Skin and subcutaneous tissue disorders 10020864 Hypertrichosis

Hair density or length beyond the accepted limits of normal for a

particular age, race, or sex (may be generalized or localized)

Skin and subcutaneous tissue disorder

1002101

Hypohidrosi

Reduced sweatin

Skin and subcutaneous tissue disorder

1006231

Lipohypertroph

ccumulation of fat under the ski

Skin and subcutaneous tissue disorder

10028691 Nail discoloratio

Change in finger or toenail colo

Skin and subcutaneous tissue disorder

10049281 Nail los

Loss of some or all of the finger or toenail

Skin and subcutaneous tissue disorders 10062283 Nail ridging Appearance of vertical or horizontal ridges on the finger or toenails

Skin and subcutaneous tissue disorder

1003347

Pain of ski

Pain of the ski

Skin and subcutaneous tissue disorders 10054524

Palmar-plantar erythrodysesthesia

syndrome

Swelling and redness of the skin on the palms of the hands an

soles of the feet

Skin and subcutaneous tissue disorder

10054541 Periorbital edem

Swelling in or around the eyelid

Skin and subcutaneous tissue disorder

1003496

Photosensitivit

Increased skin sensitivity to sunligh

Skin and subcutaneous tissue disorder

1003708

Pruritu

Itching

Skin and subcutaneous tissue disorders 10037549 Purpura

rea of bleeding within the skin causing a reddish purpl

discoloration

Skin and subcutaneous tissue disorder

1003784

Rash acneiform

cne

Skin and subcutaneous tissue disorders 10037868 Rash maculo-papular

Skin rash with the presence of macules (flat discolored area) and

papules (raised bump)

Skin and subcutaneous tissue disorder

1004912

Scalp pai

Pain in the scal

Skin and subcutaneous tissue disorders 10040785

Skin and subcutaneous tissue disorders -

Other, [add AE here] N/A

Skin and subcutaneous tissue disorder

1004079

Skin atroph

Thinning of the ski

Skin and subcutaneous tissue disorder

1004086

Skin hyperpigmentatio

Darkening of the ski

Skin and subcutaneous tissue disorder

1004086

Skin hypopigmentatio

Lightening of the ski

Skin and subcutaneous tissue disorder

1005183

Skin induratio

Hardening of an area of ski

Skin and subcutaneous tissue disorder

1004094

Skin ulceratio

Sore or destruction of ski

Skin and subcutaneous tissue disorders 10042033 Stevens-Johnson syndrome

Potentially life-threatening condition affecting less than 10% of th

skin in which cell death causes the epidermis (outer layer) to

separate from the dermis (middle layer)

Skin and subcutaneous tissue disorder

1004318

Telangiectasi

"Spider veins" (enlarged blood vessels near the skin surface

)

Skin and subcutaneous tissue disorders 10044223 Toxic epidermal necrolysis

Life-threatening condition affecting greater than 30% of the skin i

which cell death causes the epidermis (outer layer) to separate

from the dermis (middle layer)

Skin and subcutaneous tissue disorder

1004673

Urticaria Hives

Social circumstances 10027308 Menopause

Permanent stopping of a woman's period (usually defined as a tim

greater than 12 months) after 45 years-of-age

Social circumstances 10041244 Social circumstances - Other, [add AE here] N/A

Surgical and medical procedures 10042613

Surgical and medical procedures - Other,

[add AE here] N/A

Vascular disorders 10007196 Capillary leak syndrome

Increase in the number and size o

the pores in the capillarie

(small blood vessels) which causes leakage of fluid from the blood

to the tissue spaces, resulting in dangerously low blood pressure,

swelling and multiple organ failure

Vascular disorder

1001682

Flushin

Sudden reddening of the face and/or nec

Vascular disorder

1001942

Hematoma Collection of blood in tissue (bruise

)

Vascular disorder

1002040

Hot flashe

Vascular disorder

1002077

Hypertensio

High blood pressure

Vascular disorder

1002109

Hypotensio

Low blood pressur

Vascular disorders 10065773 Lymph leakage

Leakage of the clear fluid (lymph) that travels through the lymphati

vessels and carries cells that help fight infections and other

diseases

Vascular disorders 10025233 Lymphedema

Swelling of tissues due to excessive collection of lymph (the clea

fluid that is collected from tissues throughout the body) due to a

blockage in the lymphatic vessels

Vascular disorders 10048642 Lymphocele

Mass surrounded by an abnormal sac that contains lymph (the clea

luid that is collected from tissues throughout the body)

Vascular disorder

1003457

Peripheral ischemi

Poor blood supply to extremities (arms and/or legs

)

Vascular disorder

1003487

Phlebiti

Inflammation (swelling and redness) of a vein; blood clo

Vascular disorders 10042554 Superficial thrombophlebitis

Blood clot in a vein near the surface of the skin in the extremitie

(arms and/or legs)

Vascular disorders 10042569 Superior vena cava syndrome

Blockage of blood flow in the superior vena cava (the large vein tha

carries blood from the upper body to the heart)

Vascular disorders 10043565 Thromboembolic event

Formation of a blood clot that plugs the blood vessel; blood clots

may break loose and travel to another place, such as the lung

Vascular disorder

1004706

Vascular disorders - Other,[add AE here

]

Vascular disorder

1004711

Vasculiti

Inflammation (swelling and redness) of the blood vessel

Vascular disorders 10054692 Visceral arterial ischemia

Blockage or narrowing of a visceral artery (a blood vessel that

carries blood from the heart) located in an internal organ